Seminoma WikipediaMicrograph of a testicular seminoma. H&E stain. Histologic characteristics of seminoma: fried egg-like cells (clear cytoplasm with a central nucleus), nuclei have a squared-off nuclear contour/are polygonal (normal = ovoid or circular), a lymphocytic infiltration is common. Courtesy NephronMicrograph of a seminoma. H&E stain. Features: Lymphocytes. Tumour cells with a fried egg-like appearance: Central nucleus with nucleolus. Clear cytoplasm. Well-defined cell borders. Related images Intermed. mag. High mag. Seminoma in the rete testis. Courtesy Nephron
Mixed germ cell tumor containing embryonal carcinoma, seminoma, and yolk sac tumor. The embryonal carcinoma component (upper left, upper right, and lower left) shows pseudoglandular growth with high-grade features of large, epithelioid, anaplastic cells with prominent nucleoli, indistinct cell borders with nuclear overlapping, pleomorphism, and frequent mitoses. The seminoma component (upper center) shows large, round-polyhedral cells with distinct cell membranes, abundant clear/watery cytoplasm, large central nuclei and prominent nucleoli. The yolk sac component (lower right, hugging the embryonal component) exhibits microcystic/reticular growth pattern. Courtesy Difu Wu
